Dr. Amgad Albohy
Lecturer of Pharmaceutical Chemistry
Building K, Room 326

Dr. Amgad Albohy is a lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, BUE. He got his PhD in Chemical Biology from the University of Alberta, Canada and was working at the Alberta Glycomics Centre. He was trained in both Friedrich Schiller University in Germany and the Complex Carbohydrate Research Center (CCRC), University of Georgia, USA.

Dr. Albohy’s research focuses on the design of selective inhibitors among closely related isozymes. He worked in the design of inhibitors targeting human sialidases and cyclooxygenases. He is also interested in protein expression, enzyme assays development and optimization, enzyme kinetics and STD NMR.

Dr. Albohy is a registered clinical pharmacist with Alberta Collage of Pharmacists, Canada. He also holds Additional Prescribing Authority (APA) and is a certified Diabetic Educator (CDE) from Diabetes Canada.

Education
  • PhD in Chemistry:

Chemistry Department, University of Alberta, Edmonton, Alberta, Canada. 

  • Master of Science in pharmaceutical chemistry:

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt, in collaboration with the Department of Medicinal Chemistry, Faculty of Biology and Pharmacy, Friedrich-Schiller University, Jena, Germany.     

  • Bachelor of Science in pharmaceutical sciences:

Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt. Excellent grade with honor

 

 

Research Interests

Dr. Albohy’s research focuses on the design of selective inhibitors among closely related isozymes. He worked in the design of inhibitors targeting human sialidases and cyclooxygenases. He is also interested in protein expression, enzyme assays development and optimization, enzyme kinetics and STD NMR.

Journal Articles

Sherif  Ebada, Nariman Al-Jawabri, Fadia Youssef,  Amgad Albohy, Sa’ed Aldalaien, Ahmad Disi, Peter Proksch,. In vivo antiulcer activity, phytochemical exploration, and molecular modelling of the polyphenolic-rich fraction of Crepis sancta extract. Inflammopharmacology, 2019. 10.1007/s10787-019-00637-x.

 

Amgad Albohy, Michele R. Richards, Christopher W. Cairo, Mapping substrate interactions of the human membrane-associated neuraminidase, NEU3, using STD NMR, Glycobiology, 2015, 25, 284-293

 

Victoria Smutova, Amgad Albohy, Xuefang Pan, Elena Korchagin, Taeko Miyagi, Nicolai Bovin, Christopher W. Cairo, Alexey V. Pshezhetsky, Structural basis for substrate specificity of mammalian neuraminidases, PLoS One, 2014, 9,  UNSP e106320

 

Amgad Albohy, Yi Zhang, Victoria Smutova, Alexey V. Pshezhetsky,  and Christopher W. Cairo, Identification of selective nanomolar inhibitors of the human neuraminidase, NEU4, ACS Medicinal Chemistry Letters, 2013, 4, 532-437.

 

Yi Zhang, Amgad Albohy, Yao Zou, Victoria Smutova, Alexey V. Pshezhetsky, and Christopher W. Cairo, Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-Modified 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues, Journal of Medicinal Chemistry, 2013, 56, 2948-2958.

 

Mahendra S Sandbhor, Naoto Soya, Amgad Albohy, Ruixiang Blake Zheng, Jonathan Cartmell, David Reginald Bundle, John S. Klassen, and Christopher W. Cairo, Substrate recognition of the membrane associated sialidase NEU3 requires a hydrophobic aglycon, Biochemistry, 2011, 50, 6752-6762.

 

Amgad Albohy, Sankar Mohan, B. Mario Pinto and Christopher W. Cairo, Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes, Bioorganic & Medicinal Chemistry, 2011, 19, 2817-2822.

 

Yao Zou, Amgad Albohy, and Christopher W. Cairo, Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetylneuraminic acid, Bioorganic & Medicinal Chemistry Letters, 2010, 20, 7529-7533.

 

Amgad Albohy, Matthew D. Li , Ruixiang Blake Zheng, Chunxia Zou and Christopher W. Cairo, Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site directed mutagenesis, Glycobiology, 2010, 20, 1127-1138.

 

Christopher W. Cairo, Raibatak Das, Amgad Albohy, Quentin J. Baca, Deepti Pradhan, Jon S. Morrow, Daniel Coombs, and David E. Golan, Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells, Journal of biological chemistry, 2010, 285, 11392-11401.

 

Mohamed A. H. Ismail, Jochen Lehmann, Dalal A. Abou El Ella, Amgad Albohy and Khaled A. M. Abouzid, Lonazolac analogues: molecular modeling, synthesis and in vivo anti-inflammatory activity, Medicinal Chemistry Research, 2009, 18, 725-744.

Conference Papers

Amgad Albohy, Michele R. Richards, Yi Zhang, and Christopher W. Cairo, Studies towards the design of potent selective inhibitors for human sialidases (poster), The 10th National Carbohydrate Symposium, May 7-9, 2014, Banff, AB, Canada.

 

Amgad Albohy, Yi Zhang, Victoria Smutova, Alexey V. Pshezhetsky, and Christopher W. Cairo, Achieving inhibitor selectivity among human neuraminidase isoenzymes, (talk), The 96th Canadian Chemistry Conference (CSC2013), May 26-30, 2013, Quebec City, Quebec, Canada.

 

Amgad Albohy, Michele R. Richard and Christopher W. Cairo, Interactions of glycolipid substrates with the human neuraminidase enzyme, NEU3 (poster), The 9th National Carbohydrate Symposium, May 8-10, 2013, Banff, AB, Canada.

 

Amgad Albohy, Yi Zhang, Yao Zou and Christopher W. Cairo, Specificity of DANA- based inhibitors for the human sialidases (poster), The 8th  National Carbohydrate Symposium, May 9-11, 2012, Banff, AB, Canada.

 

Amgad Albohy and Christopher W. Cairo, STD-NMR studies of the human membrane-associated sialidase (NEU3) (talk), Banff symposium on organic chemistry (BSOC), November 10-13, 2011, Banff, AB, Canada.

 

Amgad Albohy, Yao Zou, Mahendra Sandbhor, Naoto Soya, R. Blake Zheng, Jonathan Cartmell, David R. Bundle, John S. Klassen and Christopher W. Cairo, Evaluation of the role of different GM3 components for binding to the human membrane associated sialidase (NEU3) (poster), The 7th National carbohydrate symposium, May 2-7, 2011, Banff, AB, Canada.

Amgad Albohy, Yao Zou, M.D. Li, Ruixiang Blake Zheng, Chunxia Zou, and Christopher W. Cairo, Exploring the mammalian neuraminidase (NEU3) active site through inhibitor design (poster), The International Chemical Congress of Pacific Basin Societies (Pacifichem 2010), December 15-20, 2010, Honolulu, Hawaii, U.S.A.

 

Amgad Albohy, Matthew D. Li, Ruixiang Blake Zheng, Chunxia Zou, and Christopher W. Cairo, Structure and substrate recognition of the mammalian neuraminidase, NEU3 (poster),  17th Canadian Symposium on Theoretical Chemistry (CSTC 2010), July 25-30, 2010, Edmonton, AB, Canada.

 

Amgad Albohy, Matthew D. Li, Ruixiang Blake Zheng, Chunxia Zou, and Christopher W. Cairo, Structure and substrate recognition of the mammalian neuraminidase, NEU3 (talk)  The 6th National carbohydrate symposium, May 6-8, 2010, Banff, AB, Canada

 

Amgad Albohy, M.D. Li, R.B. Zhang, and C.W. Cairo, Characterization of human membrane associated sialidase using site directed mutagenesis (poster), Banff symposium on organic chemistry (BSOC), Oct 29- Nov 1, 2009, Banff, AB, Canada.

Awards
  • First Canadian Society of Chemistry (CSC) 2013 Student Oral Prize, Glycochemistry and Glycobiology session, The 96th Canadian Chemistry Conference (CSC2013), May 2013.
  • Faculty of Graduate Studies and Research (FGSR) travel award, University of Alberta, June 2013.
  • Queen Elizabeth II (QE II) Scholarship, Department of Chemistry, University of Alberta, Fall 2013.
  • Graduate Students Association (GSA) professional development award, May 2013.
  • Department of Chemistry research assistantship award (RA), University of Alberta, Fall 2012 and Winter 2013.
  • Boehringer Ingelheim Award: Awarded annually to a graduate student who is demonstrating strong academic results and excellence in research, March 2012.
  • Alberta Innovates- Health Solutions (AI-HS) grant, provincial grant, Alberta, Canada, January - December 2011.
  • Partnership and Ownership Initiative (ParOwn 0906), Ministry of Higher Education and Scientific Research, Egypt. National competition, February – August 2007.